Mgf (Igf-1) Gg Gene (Rs6220) And Low-Risk In Aa Associated To Breast Cancer Risk
| Autor | Mojgan Hosseini |
| Cargo | Islamic Azad University, Department of Science, Islamshahr Branch, , Sayad Shirazi St. Islamshahr, Tehran, Iran |
| Páginas | 665-660 |
QUID 2017, pp. 655-660, Special Issue N°1- ISSN: 1692-343X, Medellín-Colombia
MGF (IGF-1) GG GENE (RS6220) AND LOW-RISK IN AA ASSOCI ATED TO BREAST CANCER
RISK
(Recibido el 21-06-2017. Aprobado el 08-09-2017)
Mojgan Hosseini
Islamic Azad University, Depar tment
of Science, Islamshahr Branch, , Sayad
Shirazi St. Islamshahr, Tehra n, Iran.
mojgan-Hosseini@iiau.a c.ir;
Abstract. Genetic factors and also as polymorphisms b e associated to breast cancer. Breast cancer (BC) first of
among death in women. This current study was determined the frequency MGF (IGF-1) Gene polymorphism in
patients with breast cancer. The Mast cell growth fac tor gene polymorphism were associated with ris k breast
cancer. MGF is regulate to cell apoptosis, prolife, and differentiation. Present study to finds that MGF gene
polymorphism has a relation with the risk of breast cancer. T wo polymorphic variants (rs6220 and rs7136446)
are associated to breast cancer. First time, we evaluated these stud y of 126 breast cancer and 160 controls Iranian
women of peripheral blood, and then did extracted DNA using the genotyping technique by sequencing. In
present study, MGF GG gene (rs6220) had significant association with breast cancer (37.3% freq uency, Odd
Retio;2.359, CI 0.208-3.621, P value; 0.001).
Keywords: MGF gene, polymorphism, breast cancer.
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